Enteral and parenteral nutrition

Outline the dose, composition and side effects of enteral and parenteral feeds

Dosing is explored here.

The composition and many adverse effects of enteral and parenteral nutrition are similar. However they differ in some key areas:

ComponentEnteralParenteral
Macronutrients
Energy1000 to 1200 kcal/L
WaterIsotonic

Hypertonic (1800 mOsm/kg)
pH ~ 5.6

Carbohydrates

125g/L carbohydrates as glucose (500 kcal/L)

Protein
  • 50g/L protein as amino acids (200 kcal/L)
  • contains all 9 essential amino acids
    • lycine
    • leucine
    • isoleucine
    • threonine
    • methionine
    • valine
    • histidine
    • tryptophan
    • phenylalanine
Lipids
  • 40g/L (360 kcal/L) lipids as soy and/or olive oil (+/- fish)
  • contains both essential fatty acids (linoleic acid and alpha-linolenic acid)
Micronutrients
Vitamins

Fat soluble vitamins: A, D, E, K

Water soluble vitamins: B vitamins (B1-3, B5-7, B9, B12), C

Trace elements

Examples: iron, selenium, chromium, manganese, zinc, copper

Electrolytes

Na+: 40 mmol/L
K+: 30 mmol/L
Ca2+: 2.5 mmol/L
Mg2+: 5 mmol/L

Complications
Unique complications

Procedural complications:

  • endobronchial nasogastric tube placement / pneumothorax
  • aspiration
  • viscous perforation
  • surgical complications of percutaneous feeding tubes (PEG/PEJ)
    • e.g. infection, bleeding

Inadequate absorption may lead to underfeeding, which is more likely with enteral feeding.

Procedural complications of central venous access:

  • vessel erosion
  • line associated thrombus
  • central-line associated bloodstream infection (CLABSI)
  • inadverdent arterial cannulation
  • bleeding
  • pneumothorax
  • air embolus

Infection

  • predisposes to fungal infection due to fungal growth in the feeding solution
  • predisposes to GI bacterial infection
    • lack of enteral nutrition leads to โ†“ stimulation of the GI tract
    • โ†’ decreased GI blood flow and mucous production
    • โ†’ increased risk of GI infection

Hypertonic fluid load predisposes to hypertonic dehydration.

Shared complications
  • Overfeeding
    • too much sugar โ†’ hyperglycaemia, insulin resistance
    • too much protein โ†’ uraemia, hyperammonaemia
    • too much lipids โ†’ hypertriglyceridaemia, fatty liver, pancreatitis
    • too much volume โ†’ hypervolaemia
  • Underfeeding
    • not meeting caloric requirements
    • catabolism, muscle wasting
    • micronutrient deficiency
    • hypovolaemia
  • Refeeding syndrome โ†’ electrolyte derangement